Introduction to epigenetic mechanisms Epigenetics encompasses the set of mechanisms that modulate gene expression without altering the DNA sequence. These processes include DNA methylation, histone modifications, chromatin remodeling, regulation by...
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The Laboratory of Environmental and Translational Epigenetics (LETE) arises from the integration of the expertise of Valentina Bollati, a pioneer in environmental epigenetics, Elia Biganzoli, an expert in biostatistics, epidemiology and sustainable artificial intelligence, and Patrizia Boracchi, an epidemiologist and biostatistician with long-standing experience in modeling public health data.
The laboratory aims to promote interdisciplinary research on the mechanisms through which environmental, social and behavioral factors influence the human epigenome and the biological processes underlying health and disease.
In close synergy with INES – Institute of Epigenetics for Smiles, LETE seeks to develop and apply integrated approaches in molecular epidemiology, multi-omics and data science to understand how environmental exposures and lifestyle shape individual and population health. The laboratory is committed to generating knowledge that supports prevention, biomedical innovation and the promotion of a sustainable model of well-being.
The sections below describe the main themes on which our research activity is focused.
The concept of Epigenetic Intelligence (EI) is rooted in the idea that the epigenome is not merely a collection of switches regulating gene expression, but a true information-processing system, capable...
Read moreTumor dormancy is a condition in which disseminated tumor cells or micrometastases remain in a quiescent state for years or even decades, escaping treatments and immune surveillance. This is not...
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