{"id":711,"date":"2023-09-20T11:04:36","date_gmt":"2023-09-20T09:04:36","guid":{"rendered":"https:\/\/lete.wpmultisite.unimi.it\/collaborations\/"},"modified":"2025-11-20T16:49:00","modified_gmt":"2025-11-20T15:49:00","slug":"collaborations-ecosystem","status":"publish","type":"page","link":"https:\/\/lete.unimi.it\/en\/who-we-are\/collaborations-ecosystem\/","title":{"rendered":"Collaborations & Ecosystem"},"content":{"rendered":"\n
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The scientific network that shapes our research questions<\/em><\/p>\n<\/blockquote>\n\n\n\n

The research we conduct at LETE does not emerge in isolation.
The complexity of the exposome, epigenetic mechanisms and biological resilience requires a broad, dynamic, and interdisciplinary network of expertise.
For this reason, we work within a collaborative ecosystem that brings together clinical sciences, molecular biology, epidemiology, statistics, bioinformatics, technology, and environmental research.<\/p>\n\n\n\n

Our collaborations go far beyond co-authorship: they are long-standing partnerships built on shared project design, common infrastructures, and translational applications.<\/p>\n\n\n\n

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<\/div>\n\n\n\n

1. Clinical Collaborations<\/strong><\/h2>\n\n\n\n

From hospital practice to biological trajectories<\/em><\/h3>\n\n\n\n

We work closely with clinical units that address the daily challenges of public health and personalized medicine.
Together, we investigate how an individual\u2019s biological state \u2014 shaped by the exposome and the epigenome \u2014 influences diagnostic, prognostic, and therapeutic pathways.<\/p>\n\n\n\n

Main partners:<\/strong><\/p>\n\n\n\n

    \n
  • Ospedale Luigi Sacco \u2014 Occupational Medicine, Pulmonology<\/li>\n\n\n\n
  • Clinica Mangiagalli \u2014 Pregnancy, Menopause, Endocrine Gynecology<\/li>\n\n\n\n
  • Policlinico Hospital \u2014 Oncology, Public Health<\/li>\n\n\n\n
  • National collaborations in oncology (PhActHealth) and sports medicine (HEBE)<\/li>\n\n\n\n
  • International collaborations in oncology (Leuven)<\/li>\n<\/ul>\n\n\n\n

    Shared areas:<\/strong>
    Ageing, inflammation, cancer, preoperative resilience, cardio-metabolic risk, maternal\u2013infant health.<\/p>\n\n\n\n

    \n\n\n\n
    <\/div>\n\n\n\n

    2. Environmental & Urban Health Collaborations<\/strong><\/h2>\n\n\n\n

    From city sensors to exposome mapping<\/em><\/h3>\n\n\n\n

    We study the environment using tools ranging from proximity sensors to advanced remote sensing techniques and spatially integrated models.<\/p>\n\n\n\n

    Main partners:<\/strong><\/p>\n\n\n\n

      \n
    • Municipality of Legnano (MAMELI Living Lab)<\/li>\n\n\n\n
    • University of Insubria \u2014 Air pollution & sensor networks<\/li>\n\n\n\n
    • University of Bari \u2014 Urban forestry & environmental planning<\/li>\n\n\n\n
    • Engineering and urban geography groups (POLIMI)<\/li>\n<\/ul>\n\n\n\n

      Shared areas:<\/strong>
      Air quality, urban environment, green exposure, livability, LiDAR, GIS, urban exposome.<\/p>\n\n\n\n

      \n\n\n\n
      <\/div>\n\n\n\n

      3. Methodological Collaborations<\/strong><\/h2>\n\n\n\n

      Biostatistics, interpretable AI and multi-omic modelling<\/em><\/h3>\n\n\n\n

      Our projects integrate epidemiological design, advanced statistics, sustainable machine learning and multi-level analyses of biological data.<\/p>\n\n\n\n

      Main partners:<\/strong><\/p>\n\n\n\n

        \n
      • KU Leuven \u2014 Statistical genomics & cancer dormancy<\/li>\n\n\n\n
      • Italian Institute of Technology (IIT) \u2014 Repetitive element methylation<\/li>\n\n\n\n
      • University of Parma \u2014 Cellular models and translational cardiology<\/li>\n<\/ul>\n\n\n\n

        Shared areas:<\/strong>
        Causal inference, non-linear models, exposome-wide association, multi-omic networks, explainable AI, biological ageing algorithms.<\/p>\n\n\n\n

        \n\n\n\n
        <\/div>\n\n\n\n

        4. Collaborations on Extracellular Vesicles & Molecular Signalling<\/strong><\/h2>\n\n\n\n

        From microRNA to systemic information flows<\/em><\/h3>\n\n\n\n

        We collaborate with teams specialized in EV biology and epigenetic intercellular communication \u2014 a core area of our research.<\/p>\n\n\n\n

        Main partners:<\/strong><\/p>\n\n\n\n

          \n
        • UNIMI \u2014 EVs & ageing groups<\/li>\n\n\n\n
        • Clinical collaborations on maternal\u2013fetal, oncologic and inflammatory EVs<\/li>\n<\/ul>\n\n\n\n
          \n\n\n\n
          <\/div>\n\n\n\n

          5. Third Mission & Community Engagement<\/strong><\/h2>\n\n\n\n

          Transferring knowledge, co-producing well-being<\/em><\/h3>\n\n\n\n

          We collaborate with local institutions, schools, associations and community groups to support:<\/p>\n\n\n\n

            \n
          • scientific outreach on environment and health<\/li>\n\n\n\n
          • awareness on positive lifestyle behaviours<\/li>\n\n\n\n
          • INES initiatives on well-being, perception and resilience<\/li>\n\n\n\n
          • urban policies oriented toward public health<\/li>\n<\/ul>\n\n\n\n
            \n\n\n\n
            <\/div>\n\n\n\n

            6. Our Way of Collaborating<\/strong><\/h2>\n\n\n\n

            Multidisciplinary, open, interpretative, translational<\/em><\/h3>\n\n\n\n

            All collaborations at LETE share four core principles:<\/p>\n\n\n\n

              \n
            • Genuine interdisciplinarity<\/strong>, not just formal<\/li>\n\n\n\n
            • Methodological rigour<\/strong>, from data collection to causal modelling<\/li>\n\n\n\n
            • A culture of reproducibility<\/strong> and interpretable data<\/li>\n\n\n\n
            • A translational vocation<\/strong>, from molecular mechanisms to community impact<\/li>\n<\/ul>\n\n\n\n

              Collaborating, for us, means building \u2014 together \u2014 a new way of reading the relationship between environment, biology and health.<\/p>\n","protected":false},"excerpt":{"rendered":"

              Our collaborators<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":774,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-711","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/lete.unimi.it\/en\/wp-json\/wp\/v2\/pages\/711"}],"collection":[{"href":"https:\/\/lete.unimi.it\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lete.unimi.it\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lete.unimi.it\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/lete.unimi.it\/en\/wp-json\/wp\/v2\/comments?post=711"}],"version-history":[{"count":12,"href":"https:\/\/lete.unimi.it\/en\/wp-json\/wp\/v2\/pages\/711\/revisions"}],"predecessor-version":[{"id":1252,"href":"https:\/\/lete.unimi.it\/en\/wp-json\/wp\/v2\/pages\/711\/revisions\/1252"}],"up":[{"embeddable":true,"href":"https:\/\/lete.unimi.it\/en\/wp-json\/wp\/v2\/pages\/774"}],"wp:attachment":[{"href":"https:\/\/lete.unimi.it\/en\/wp-json\/wp\/v2\/media?parent=711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}